Protein Details: Cyclic nucleotide-gated ion channel 1

Protein ID

ICDB_Pro_0242

Protein Name

Cyclic nucleotide-gated ion channel 1

Gene Name

CNGC1 At5g53130 MFH8.6

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

716 amino acids

AlphaFoldDB

AF-O65717-F1-model_v4.pdb

Function

Acts as a cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K(+), Na(+) and Pb(2+).

Sequence

MNFRQEKFVRFQDWKSDKTSSDVEYSGKNEIQTGIFQRTISSISDKFYRSFESSSARIKLFKRSYKSYSFKEAVSKGIGSTHKILDPQGPFLQRWNKIFVLACIIAVSLDPLFFYVPIIDDAKKCLGIDKKMEITASVLRSFTDVFYVLHIIFQFRTGFIAPSSRVFGRGVLVEDKREIAKRYLSSHFIIDILAVLPLPQMVILIIIPHMRGSSSLNTKNMLKFIVFFQYIPRFIRIYPLYKEVTRTSGILTETAWAGAAFNLFLYMLASHVFGAFWYLFSIERETVCWKQACERNNPPCISKLLYCDPETAGGNAFLNESCPIQTPNTTLFDFGIFLDALQSGVVESQDFPQKFFYCFWWGLQNLSSLGQNLKTSTYIWEICFAVFISIAGLVLFSFLIGNMQTYLQSTTTRLEEMRVKRRDAEQWMSHRLLPENLRKRIRRYEQYKWQETRGVDEENLLSNLPKDLRRDIKRHLCLALLMRVPMFEKMDEQLLDALCDRLQPVLYTEESYIVREGDPVDEMLFIMRGKLLTITTNGGRTGFLNSEYLGAGDFCGEELLTWALDPHSSSNLPISTRTVRALMEVEAFALKADDLKFVASQFRRLHSKQLRHTFRYYSQQWKTWAACFIQAAWRRYIKKKLEESLKEEENRLQDALAKEACGSSPSLGATIYASRFAANILRTIRRSGSVRKPRMPERMPPMLLQKPAEPDFNSDD

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 486..610; /ligand="a nucleoside 3,5-cyclic phosphate"; BINDING 557; /ligand="a nucleoside 3,5-cyclic phosphate"

Disease

Location

Expressed in the whole plant but only weakly in roots.

DOI ID

10.1111/tpj.13415; 10.1126/science.1088305; 10.1046/j.1365-313x.1999.00422.x; 10.1016/s0014-5793(00)01383-1; 10.1046/j.1365-313x.2000.00901.x; 10.1104/pp.126.4.1646; 10.1104/pp.010832

RefSeq

NP_200125.1